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New scientific review finds insufficient data to draw accurate conclusions about the association of PFAS with any specific disease

CHICAGO (Jan. 26, 2022) — A new critical review of existing research on per- and polyfluoroalkyl substances (PFAS) found that most PFAS studies to-date include insufficient data to draw accurate conclusions about the association of PFAS with any specific disease.

A central recommendation from the authors is the need for additional specific research to properly calculate human-relevant dose to further link associations with human risk assessment and help set tolerable daily intake.

The critical review is featured in the latest issue of Environmental Research, a peer-reviewed environmental science and environmental health journal, and was performed by the Center of Environmental Food and Toxicological Technology at the University of Rovira i Virgili in Spain.

“This critical review highlights how a greater emphasis must be placed on developing workable and effective risk assessment methods for human health, including integrative translational toxicology to support regulatory processes and the development of relevant policy-related strategies for PFAS,” said Vikas Kumar, Ph.D., lead research scholar for the critical review.

This critical review was funded by the Center for Truth in Science, an independent non-profit organization dedicated to exploring the intersection of science, justice and the economy.

“This scientific review performs a meticulous analysis of what is known and unknown surrounding PFAS chemicals,” said Joseph Annotti, president and CEO and Board Member of the Center for Truth in Science. “It is my hope that this review provides a framework for researchers going forward and for how we, as a scientific community, can perform the most useful analysis of a compound’s effects on the human body.”

This is the first critical review where highly referred articles on PFAS used for policymaking by several regulatory agencies were collected and evaluated based on the review guidelines developed by the U.S. National Toxicology Program’s Office of Health Assessment and Translation review guidelines.

This new research provides key insight for improving methodological protocols for future PFAS experimental studies. The critical review was performed in accordance with PRISMA guidelines, the most rigorous set of internationally accepted criteria guiding the reporting of systematic reviews and meta-analyses.

To view the full critical review, visit Framework for risk assessment of PFAS utilizing experimental studies and in-silico models – Environmental Research, Volume 208, 2022.

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